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| Experimental Biology Research Instruments: New Online Videos | |
| EB-Instruments.com is now offering researchers a new exclusive content: online videos that can be played YouTube-style, directly from the web page of the research instruments for all your applications in nociception, behaviour, motor activity and anxiety.
This new feature on EB-Instruments's website allows researchers to instantaneously get a video demonstration of some of the most acclaimed instruments developed by our partner, Bioseb: Grip Strength Test, Activity Wheel, ActiV_meter, Dynamic Weight Bearing - Incapacitance, Thermal Gradient Test, Infrared Thermometer, Automated Forced Swimming Test, 2 Temperatures Choice Test, Electronic Von Frey Further instruments developed by other partners also feature the new video content: Rotarod, Black & White Test, Forced Swimming Test for Rats (Porsolt) Just click on the name of an instrument in the lists above, and use the "Video" button to play the demonstration directly from your browser. More videos are available for registered users - please register on EB-Instruments.com and contact us to obtain the download link to specific videos. If you are interested in obtaining a video for an instrument but cannot find it on our website, please contact us and we will do our best to put a new demonstration online. |
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| Dynamic Weight Bearing - Publication | |
| The EB-Instruments team presents its respectful thanks to following research teams who used the Dynamic Weight Bearing (New Incapacitance Test) during their recent studies: • Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada) Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model, by Louis Doré-Savard, Valérie Otis, Luc Tremblay, Karine Belleville, Mélanie Archambault et al. (Click here to send a download request for this research poster as a PDF file) • Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada) Improving Pain Assessment In A New Mouse Model Of Bone Cancer Pain, by G. Roussy, K. Belleville, N. Beaudet and P. Sarret (Click here to send a download request for this research poster as a PDF file) • Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada) NTS2 receptor activation as an innovative target for the treatment of neuropathic pain, by P.G. Tétreault, A. Guillemette, K. Belleville, J. Martinez, N. Beaudet and P. Sarret (Click here to send a download request for this research poster as a PDF file)    Click on a picture to send a download request for a research poster • Team of Dr. Ungard (McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada) Examination of the mechanisms of cancer-induced bone pain in animal models, by Robert Ungard, Eric Seidlitz, Paolo De Ciantis, Vikas Sridhar, Kiran Yashpal, James L. Henry and Gurmit Singh (Click here to send a download request for this research poster as a PDF file) • Team of Dr. Bagi (WWCM, Global Science and Technology, Pfizer Inc., Groton) Effect of VEGF inhibitor PF-00337210 and FAK/Pyk2 inhibitor PF-562,271 on Intra-tibial Growth of Breast Cancer Cells in Nude Rats and Mice, by Cedo M. Bagi, Rich Pero, Edwin Berryman, Daniel Aupi, Dean Wilkie and Cathy J. Andresen (Click here to send a download request for this research poster as a PDF file) 
Click on a picture to send a download request for a research poster |
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| Activ_Meter (Actimeter for Rodents) - Publication | |
| EB-Instruments team presents its respectful thanks to research teams of Prof. David (Université Paris-Sud) and Prof. Samuels (Columbia University, New York), who used the Activ_Meter (Actimeter for Rodents) during their recent studies:
Behavioral Effects of Fluoxetine in an Animal Model of Anxiety/Depression Are Mediated by Both Neurogenesis-Dependent and -Independent Mechanisms, by DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al., in Neuron, 62, 2009 (Click here to download this article as a PDF file) Abstract Using Bioseb's Activ_Meter (Actimeter for Rodents), DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al could describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment, and showed that chronic antidepressant treatment reversed the behavioral dysfunctions and the inhibition of hippocampal neurogenesis induced by corticosterone treatment. Home cage activity was quantified using the ActiV-Meter (Bioseb, Vitrolles, France) over a 24 hours period. During the experiment, food and water were provided ad libitum. Various parameters such as activity time (sec), ambulatory distance (cm) and inactivity duration (calculated from the difference between immobility and motionless activity duration while the animal is eating or scratching) were recorded. These results demonstrate the interest of Bioseb's Bioseb's ActiV_Meter (Actimeter for rodents) for monitoring activity and locomotion of rodents (mouse and rat) in the home cage. Click here to know more about Bioseb's ActiV_Meter (Actimeter for rodents) |
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| Thermal Place Preference - Publication | |
| EB-Instruments team presents its respectful thanks to research teams of Prof. Lazdunski (Université de Nice-Sophia Antipolis, France) and Prof. Eschalier (Clermont Université, Clermont-Ferrand, France), who used the Two-Temperatures Choice Test during their recent studies:
The mechano-activated Kþ channels TRAAK and TREK-1 control both warm and cold perception, by J. Noe, K. Zimmermann, J. Busserolles, E. Deval, A. Alloui,S. Diochot, N. Guy, M. Borsotto,P. Reeh, A. Eschalier and M. Lazdunski, EMBO Journal, 2009 (Click here to download this article as a PDF file) Abstract The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. Using Bioseb's Two Temperaturs Choice Test, the research team could show that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol. These results demonstrate the interest of Bioseb's Thermal Place Preference (2 Temperatures Choice Nociception Test) to study thermal nociception, thus being a very valuable tool for your research on analgesia. Click here to know more about Bioseb's Thermal Place Preference (2 Temperatures Choice Nociception Test) |
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| Cold and Hot Plate Test - Publication | |
| EB-Instruments team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who used the Cold and Hot Plate Test during its recent studies:
Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents, by I. Yalcin, A. Charlet, MJ. Freund-Mercier, M. Barrot and P. Poisbeau, in The Journal of Pain, 2009 (Click here to download this article as a PDF file) Abstract Yalcin, Charlet, Freund-Mercier, Barrot and Poisbeau, using Bioseb's Hot and Cold Plate Test, could show that escape behavior (jumps) was the most appropriate parameter in C57Bl/6J mice, whereas nociceptive response was estimated by using the sum of paw lickings and withdrawals in Sprague-Dawley rats. They could also demonstrate that this procedure allows the detection of both thermal allodynia and hyperalgesia after peripheral pain sensitization with capsaicin in mice and in rats. In a condition of carrageenan-induced paw inflammation, they observed the previously described thermal hyperalgesia, but also revealed that rats exhibit a clear thermal allodynia to a cold or a hot stimulus. These results demonstrate the interest of Bioseb's Dynamic Hot and Cold plate to study thermal nociception, and more particularly to study both thermal allodynia and hyperalgesia within a single paradigm in awake and freely moving rodents. Click here to know more about Bioseb's Cold and Hot Plate Test |
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| Dynamic weight bearing : New incapacitance test | |
| Measuring the Postural Equilibrium (weight bearing) on freely moving Mice or Rats, Bioseb's Dynamic Weight Bearing is an efficient alternative to traditional incapacitance tests for your research on analgesia/nociception.
Allowing to measure independantly the weight bore by each limb of a free moving animal, this very accurate system provides you with raw datas and computed values for each paw, which are synchronized with the images from a video camera. Click here to get more information about our brand new Dynamic Weight Bearing |
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